- Severe abdominal pain
- Excessive vomiting
- Severe and prolonged diarrhea.
- Blood in the stool or urine
- Severe and prolonged constipation
- Dehydration
- Acute arthritis
- Acute gout
- Unexplained swelling or severe pain of the joint or extremity
- Unexplained bruising or bleeding under the skin
- Severe or extensive skin rashes
- Infections, abscesses, and cellulitis
- Severe asthma attack